|
KMID : 0382619840040020647
|
|
Hanyang Journal of Medicine
1984 Volume.4 No. 2 p.647 ~ p.658
|
|
|
Effects of Organophosphorus Insecticides on Cyclic Nucleotide Level in Splenic Lymphocytes and Peripheral Lymphocyte Counts in Albino Mouse
|
|
|
|
|
Abstract
|
|
|
It has been known that intracellular cNucleotide participates in the proliferation of some cells and the increase in cAMP content causes inhibition of proliferation while the. increase in cGMP causes stimulation.
The aim of the present study was to extend the investigation on the correlative relationship between altered intracellular level of cNucleotide and lymphocyte proliferation after administration of single relatively small dose of organophophorus insecticides in mouse.
1) EPN and mavidan caused the decrease in cAMP and cGMP contents and the increase in Splenic lymphocyte counts.
2) In the case of PAP, there were initial fall and later rise in cAMP level and decrease in cGMP at 2 days.
Splenic and blood lymphocyte counts were in normal range besides 61010 decrease in 7 days and 121076 increase in 1 days respectively.
3) DDVP was found to induce initial decrease in cAMP and cGMP which was followed by in-crease. Splenic lymphocyte counts were increased in 1 and 2 days but decreased in 7 days. Blood lymphocyte counts were significantly increased in 2 days.
4) Diazinon produced decrease in cAMP in all experimental period but showed no significant fluctuation in cGMP and in lymphocyte counts.
From these results, it may be concluded that organophosphorus insecticides in general cause changes in intracellular cNucleotide levels regardless of their chemical structure and all nonmitogenic agents which affect on cNucleotide level have not priori effect on lymphocyte counts.
This study suggests that proliferation of splenic lymphocyte is more dependent on cellular cAMP rather than cGMP while blood lymphocyte count is indifferent to altered cellular cNuleotide content.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|